- Mary-Catherine Lader has stepped down as President and COO of Uniswap Labs after four years
- Lader has transitioned into an advisory role while the company begins its search for a successor
- Her departure follows a period of rapid growth, including the resolution of an SEC investigation and over $73 billion in trading volume
Uniswap Labs President and Chief Operating Officer Mary-Catherine Lader has officially stepped down from her leadership role after four years at the helm. In that time, Lader has helped steer the company through both explosive growth and regulatory challenges, including the resolution of a high-profile investigation by the Securities and Exchange Commission (SEC). Lader will stay on in an advisory capacity while a replacement is sought.
A Legacy of Transformation
Lader joined Uniswap Labs in mid-2021 after a decade at BlackRock, where she served as managing director and led the firm’s Aladdin Sustainability initiative. At Uniswap, she played a pivotal role in scaling the company beyond its developer roots by building out core infrastructure across legal, HR, finance, marketing, policy, and customer operations. Her efforts helped turn the protocol into a globally recognized institution with strong internal controls and a professional executive team.
Lader announced her departure on X, hailing her time with the exchange:
Personal news: after four incredible years as President & COO of @Uniswap, I’m starting something new.
This is a new chapter for crypto. We’ve come a long way since I started digital assets at BlackRock in 2015, and building with @haydenzadams was an awesome adventure.
I’m…
— Mary-Catherine Lader (@Mclader) July 15, 2025
Notable respondents to Lader’s tweet included Coinbase CEO Brian Armstrong and Uniswap CEO Hayden Adams, both of whom wished her well with her next venture.
Major Milestones
During her tenure, Lader oversaw a $165 million Series B funding round in October 2022 that valued Uniswap Labs at $1.66 billion, as well as leading the company through one of its biggest regulatory hurdles: a Wells Notice issued by the SEC. This was ultimately dropped in early 2025 with no enforcement action taken, chiefly due to the new U.S. administration’s more lenient approach to crypto. In recent weeks, Uniswap hit a major trading milestone, surpassing $73 billion in 30-day volume, solidifying its position as Ethereum’s top decentralized exchange.
While Lader’s successor has not yet been named, Uniswap is expected to select a new president through a formal nomination and board approval process, similar to the one that brought Lader on board. Internally, speculation points to several senior figures across engineering, product, and ventures who could step up to the role. With its regulatory battles behind it and strong growth metrics in hand, the company appears well-positioned to build on Lader’s legacy and continue its expansion under new leadership.
